The lawmakers announced their resignations in separate letters to the green chamber, which were read on the floor of the house in Abuja by the Speaker, Yakubu Dogara.
Three members left the APC while a member dumped the PDP.
Adekunle Akinlade, representing Egbado South/Ipokia Federal Constituency in Ogun and Muhammed Ajanah, representing Adavi/Okehi Federal Constituency in Kogi defected from the APC to Allied Peoples Movement (APM) and PDP respectively.
Mr Salish Koko, representing Maiyama/Koko-Besse Federal Constituency in Kebbi, dumped the APC and headed for the Social Democratic Party (SDP).
Rabiu Kaugama who represents Mallam Madori/Kaugama Federal Constituency of Jigawa left the PDP for the SDP.
In the letters, the lawmakers made references to irreconcilable issues relating to the party primaries as part of the reasons for the resignation and defection.
The legislators said after due consultations with their constituents, it was time for them to part ways with the APC and PDP.
The News Agency of Nigeria (NAN) reports that a gale of defection has continued to hit the lower chamber as aftermath of the party primaries.
Many aggrieved members could not get their parties’ tickets for the 2019 elections.